Drug interactions
Mesalamine + Voclosporin
Severity: Moderate
Mesalamine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, is nephrotoxic, and mesalamine is rarely associated with interstitial nephritis and renal impairment. Using them together may raise the risk of kidney injury, which is important in lupus nephritis patients with already reduced renal function.
What this interaction means in plain words
Mesalamine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mesalamine belongs to Gastrointestinal Tract; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity from calcineurin inhibitor-induced renal vasoconstriction and mesalamine-associated interstitial nephritis.
What to do
Monitor serum creatinine and eGFR at baseline and regularly during coadministration; reduce voclosporin dose or stop the offending agent if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Mesalamine with Voclosporin?
MediHelp rates the interaction as moderate. Mesalamine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, is nephrotoxic, and mesalamine is rarely associated with interstitial nephritis and renal impairment. Using them together may raise the risk of kidney injury, which is important in lupus nephritis patients with already reduced renal function.
How serious is the interaction between Mesalamine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR at baseline and regularly during coadministration; reduce voclosporin dose or stop the offending agent if renal function declines.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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