Drug interactions
Mestranol + Mineral oil
Severity: Minor
Mestranol and Mineral oil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mineral oil is a non-absorbable lipophilic laxative that can retain fat-soluble drugs in the intestinal lumen. Oral mestranol absorption could theoretically be reduced, with a possible loss of contraceptive efficacy with frequent use.
What this interaction means in plain words
Mestranol and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mineral oil may dissolve lipophilic estrogen in the gut lumen and accelerate transit, reducing absorption.
What to do
Avoid routine mineral oil use with oral mestranol products; if needed, give mestranol at least 2 hours before mineral oil.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mineral oil
Frequently asked questions
Can I take Mestranol with Mineral oil?
MediHelp rates the interaction as minor. Mestranol and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mineral oil is a non-absorbable lipophilic laxative that can retain fat-soluble drugs in the intestinal lumen. Oral mestranol absorption could theoretically be reduced, with a possible loss of contraceptive efficacy with frequent use.
How serious is the interaction between Mestranol and Mineral oil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine mineral oil use with oral mestranol products; if needed, give mestranol at least 2 hours before mineral oil.
What other medicines interact with Mineral oil?
MediHelp also lists interactions of Mineral oil with, for example, Docusate, Vitamin k1, Beta carotene. The full list is on the Mineral oil page.
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