Drug interactions
Mestranol + Trimipramine
Severity: Minor
Mestranol and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may reduce the clearance of tricyclic antidepressants, which can raise trimipramine exposure and adverse effects, while the antidepressant response may sometimes be reduced. The evidence is limited and the effect is usually small.
What this interaction means in plain words
Mestranol and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of oxidative hepatic metabolism of the tricyclic by estrogen; not firmly established.
What to do
Monitor for tricyclic adverse effects and therapeutic response when starting or stopping the estrogen. Adjust the trimipramine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Mestranol with Trimipramine?
MediHelp rates the interaction as minor. Mestranol and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may reduce the clearance of tricyclic antidepressants, which can raise trimipramine exposure and adverse effects, while the antidepressant response may sometimes be reduced. The evidence is limited and the effect is usually small.
How serious is the interaction between Mestranol and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and therapeutic response when starting or stopping the estrogen. Adjust the trimipramine dose if needed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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