Drug interactions
Metaproterenol + Metolazone
Severity: Moderate
Metaproterenol and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol and metolazone can both reduce serum potassium, so concurrent use may cause hypokalemia. This raises the risk of cardiac arrhythmias, particularly with higher bronchodilator doses or underlying heart disease.
What this interaction means in plain words
Metaproterenol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Renal potassium loss from metolazone plus beta-2 agonist-driven intracellular potassium shift cause additive hypokalemia.
What to do
Monitor serum potassium and magnesium periodically and replace as needed. Use the lowest effective beta-agonist dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Metaproterenol with Metolazone?
MediHelp rates the interaction as moderate. Metaproterenol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol and metolazone can both reduce serum potassium, so concurrent use may cause hypokalemia. This raises the risk of cardiac arrhythmias, particularly with higher bronchodilator doses or underlying heart disease.
How serious is the interaction between Metaproterenol and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and replace as needed. Use the lowest effective beta-agonist dose.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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