Drug interactions
Metaproterenol + Midodrine
Severity: Minor
Metaproterenol and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol is a beta-agonist that can increase heart rate and cause palpitations or arrhythmia, particularly at higher doses or with systemic absorption. Combined with midodrine, additive cardiovascular stimulation is possible.
What this interaction means in plain words
Metaproterenol and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic sympathomimetic effects via alpha-1 and beta-adrenergic stimulation.
What to do
Monitor heart rate and blood pressure, especially in patients with heart disease. Use the lowest effective bronchodilator dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Metaproterenol with Midodrine?
MediHelp rates the interaction as minor. Metaproterenol and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metaproterenol is a beta-agonist that can increase heart rate and cause palpitations or arrhythmia, particularly at higher doses or with systemic absorption. Combined with midodrine, additive cardiovascular stimulation is possible.
How serious is the interaction between Metaproterenol and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, especially in patients with heart disease. Use the lowest effective bronchodilator dose.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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