Drug interactions
Metaproterenol + Tiotropium-olodaterol
Severity: Moderate
Metaproterenol and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol is a beta-agonist, so combining it with olodaterol duplicates beta2 stimulation. This can increase heart rate, tremor, palpitations, blood pressure changes and hypokalemia, and raises the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Metaproterenol and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic receptor agonism from two beta agonists.
What to do
Avoid regular concurrent use of a second beta-agonist with the long-acting combination inhaler. If it is used, monitor heart rate, blood pressure and serum potassium, and review the need for the extra agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Metaproterenol with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Metaproterenol and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol is a beta-agonist, so combining it with olodaterol duplicates beta2 stimulation. This can increase heart rate, tremor, palpitations, blood pressure changes and hypokalemia, and raises the risk of arrhythmia in susceptible patients.
How serious is the interaction between Metaproterenol and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use of a second beta-agonist with the long-acting combination inhaler. If it is used, monitor heart rate, blood pressure and serum potassium, and review the need for the extra agent.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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