Drug interactions
Metaproterenol + Trimipramine
Severity: Moderate
Metaproterenol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may potentiate the cardiovascular effects of beta-agonists such as metaproterenol, causing tachycardia, arrhythmia and blood pressure changes.
What this interaction means in plain words
Metaproterenol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation with tricyclic potentiation of vascular and cardiac responses to sympathomimetics.
What to do
Monitor heart rate, rhythm and blood pressure, particularly in patients with cardiovascular disease. Use the lowest effective metaproterenol dose or an inhaled alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Metaproterenol with Trimipramine?
MediHelp rates the interaction as moderate. Metaproterenol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may potentiate the cardiovascular effects of beta-agonists such as metaproterenol, causing tachycardia, arrhythmia and blood pressure changes.
How serious is the interaction between Metaproterenol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, particularly in patients with cardiovascular disease. Use the lowest effective metaproterenol dose or an inhaled alternative.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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