Drug interactions
Metaxalone + Methocarbamol
Severity: Moderate
Metaxalone and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These are two centrally acting skeletal muscle relaxants with sedative properties, so taking them together adds to drowsiness and dizziness without a clear therapeutic benefit. Impaired coordination and falls are a concern, especially in older adults.
What this interaction means in plain words
Metaxalone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from two sedating muscle relaxants.
What to do
Avoid using two muscle relaxants concurrently and choose a single agent at the lowest effective dose. If both are given, monitor for sedation and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Methocarbamol?
MediHelp rates the interaction as moderate. Metaxalone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. These are two centrally acting skeletal muscle relaxants with sedative properties, so taking them together adds to drowsiness and dizziness without a clear therapeutic benefit. Impaired coordination and falls are a concern, especially in older adults.
How serious is the interaction between Metaxalone and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two muscle relaxants concurrently and choose a single agent at the lowest effective dose. If both are given, monitor for sedation and fall risk.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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