Drug interactions
Metaxalone + Methohexital
Severity: Moderate
Metaxalone and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system. Combined use can cause deeper sedation and psychomotor impairment than either alone.
What this interaction means in plain words
Metaxalone and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Monitor sedation and respiratory status during and after methohexital anesthesia and reduce doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Methohexital
Frequently asked questions
Can I take Metaxalone with Methohexital?
MediHelp rates the interaction as moderate. Metaxalone and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system. Combined use can cause deeper sedation and psychomotor impairment than either alone.
How serious is the interaction between Metaxalone and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status during and after methohexital anesthesia and reduce doses as needed.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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