Drug interactions
Metaxalone + Mifepristone
Severity: Minor
Metaxalone and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a CYP3A4 inhibitor, and metaxalone is metabolised by several CYP enzymes including CYP3A4, so exposure to metaxalone could rise. Increased drowsiness and dizziness are possible, though data are limited.
What this interaction means in plain words
Metaxalone and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metaxalone belongs to Musculoskeletal; Mifepristone belongs to Endocrine.
Why it happens
Possible inhibition of CYP3A4-mediated metaxalone metabolism by mifepristone.
What to do
Monitor for increased sedation and dizziness, and lower the metaxalone dose if these occur. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Metaxalone with Mifepristone?
MediHelp rates the interaction as minor. Metaxalone and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone is a CYP3A4 inhibitor, and metaxalone is metabolised by several CYP enzymes including CYP3A4, so exposure to metaxalone could rise. Increased drowsiness and dizziness are possible, though data are limited.
How serious is the interaction between Metaxalone and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and dizziness, and lower the metaxalone dose if these occur. No routine dose change is needed.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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