Drug interactions
Metaxalone + Mitotane
Severity: Moderate
Metaxalone and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may lower metaxalone concentrations, which could reduce muscle-relaxant effect. Induction can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Metaxalone and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 and other hepatic enzymes by mitotane increases the metabolism of metaxalone.
What to do
Monitor for reduced metaxalone efficacy and consider a dose increase within labeled limits or an alternative relaxant. Reassess when mitotane is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Metaxalone with Mitotane?
MediHelp rates the interaction as moderate. Metaxalone and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may lower metaxalone concentrations, which could reduce muscle-relaxant effect. Induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Metaxalone and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced metaxalone efficacy and consider a dose increase within labeled limits or an alternative relaxant. Reassess when mitotane is stopped.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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