Drug interactions
Metaxalone + Nalbuphine
Severity: Moderate
Metaxalone and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can deepen drowsiness, slow psychomotor performance and impair alertness. Falls and accidents are more likely, especially in older or frail patients.
What this interaction means in plain words
Metaxalone and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from the opioid agonist-antagonist and the centrally acting muscle relaxant.
What to do
Start with the lowest effective doses and warn the patient against driving or operating machinery until the response is known. Reduce the dose of one or both agents if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metaxalone and Nalbuphine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Nalbuphine?
MediHelp rates the interaction as moderate. Metaxalone and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can deepen drowsiness, slow psychomotor performance and impair alertness. Falls and accidents are more likely, especially in older or frail patients.
How serious is the interaction between Metaxalone and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and warn the patient against driving or operating machinery until the response is known. Reduce the dose of one or both agents if excessive sedation occurs.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
