Drug interactions
Metaxalone + Oliceridine
Severity: Major
Metaxalone and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a centrally acting muscle relaxant can cause profound sedation, respiratory depression, coma and death. Metaxalone's mild anticholinergic activity may also add to opioid-related constipation or urinary retention.
What this interaction means in plain words
Metaxalone and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metaxalone belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid agonism and muscle relaxant sedation.
What to do
Reserve concurrent use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metaxalone
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Metaxalone with Oliceridine?
MediHelp rates the interaction as major. Metaxalone and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a centrally acting muscle relaxant can cause profound sedation, respiratory depression, coma and death. Metaxalone's mild anticholinergic activity may also add to opioid-related constipation or urinary retention.
How serious is the interaction between Metaxalone and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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