Drug interactions
Metaxalone + Orphenadrin
Severity: Moderate
Metaxalone and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and orphenadrine adds anticholinergic effects. Taken together they can cause greater drowsiness, dizziness and impaired psychomotor performance, which raises the risk of falls and accidents.
What this interaction means in plain words
Metaxalone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective doses and monitor for excessive sedation and confusion, especially in older adults. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Orphenadrin?
MediHelp rates the interaction as moderate. Metaxalone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and orphenadrine adds anticholinergic effects. Taken together they can cause greater drowsiness, dizziness and impaired psychomotor performance, which raises the risk of falls and accidents.
How serious is the interaction between Metaxalone and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation and confusion, especially in older adults. Advise patients to avoid driving and alcohol.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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