Drug interactions
Metaxalone + Oxymorphone
Severity: Moderate
Metaxalone and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone is a sedating muscle relaxant, and combining it with an opioid can increase drowsiness, dizziness and impaired psychomotor performance. Respiratory depression is possible at higher doses.
What this interaction means in plain words
Metaxalone and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and monitor sedation and respiratory status. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Oxymorphone?
MediHelp rates the interaction as moderate. Metaxalone and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone is a sedating muscle relaxant, and combining it with an opioid can increase drowsiness, dizziness and impaired psychomotor performance. Respiratory depression is possible at higher doses.
How serious is the interaction between Metaxalone and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status. Counsel patients to avoid driving and alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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