Drug interactions
Metaxalone + Quetiapine
Severity: Moderate
Metaxalone and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is markedly sedating, and combining it with metaxalone can intensify drowsiness, dizziness and psychomotor slowing. Falls and impaired driving ability are the main practical concerns.
What this interaction means in plain words
Metaxalone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through antihistaminic and other central actions.
What to do
Monitor for oversedation and orthostatic symptoms, especially after starting or raising doses. Counsel patients to avoid driving and consider reducing the muscle relaxant dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Metaxalone with Quetiapine?
MediHelp rates the interaction as moderate. Metaxalone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is markedly sedating, and combining it with metaxalone can intensify drowsiness, dizziness and psychomotor slowing. Falls and impaired driving ability are the main practical concerns.
How serious is the interaction between Metaxalone and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic symptoms, especially after starting or raising doses. Counsel patients to avoid driving and consider reducing the muscle relaxant dose.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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