Drug interactions
Metaxalone + Ramelteon
Severity: Minor
Metaxalone and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is a hypnotic that promotes sleep, and metaxalone may add to daytime or next-morning drowsiness. The effect is generally modest but can affect alertness.
What this interaction means in plain words
Metaxalone and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metaxalone belongs to Musculoskeletal; Ramelteon belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, probably mild.
What to do
Advise patients to watch for residual sedation the following morning and avoid driving if drowsy. No routine dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Metaxalone with Ramelteon?
MediHelp rates the interaction as minor. Metaxalone and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is a hypnotic that promotes sleep, and metaxalone may add to daytime or next-morning drowsiness. The effect is generally modest but can affect alertness.
How serious is the interaction between Metaxalone and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for residual sedation the following morning and avoid driving if drowsy. No routine dose change is usually needed.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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