Drug interactions
Metaxalone + Sufentanil
Severity: Major
Metaxalone and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as sufentanil combined with a sedating muscle relaxant can intensify drowsiness, impair psychomotor performance and deepen respiratory depression. The risk is greatest at higher doses and in frail or opioid-naive patients.
What this interaction means in plain words
Metaxalone and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metaxalone belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Use the lowest effective doses and shortest duration of both agents, and monitor sedation and respiratory rate closely. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metaxalone
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Metaxalone with Sufentanil?
MediHelp rates the interaction as major. Metaxalone and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids such as sufentanil combined with a sedating muscle relaxant can intensify drowsiness, impair psychomotor performance and deepen respiratory depression. The risk is greatest at higher doses and in frail or opioid-naive patients.
How serious is the interaction between Metaxalone and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and shortest duration of both agents, and monitor sedation and respiratory rate closely. Counsel patients to avoid driving and alcohol.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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