Drug interactions
Metaxalone + Thioridazine
Severity: Moderate
Metaxalone and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is a sedating phenothiazine, and together with metaxalone it can cause additive drowsiness and psychomotor impairment. Thioridazine also carries a QT prolongation risk, which is not altered by metaxalone but warrants attention in the overall regimen.
What this interaction means in plain words
Metaxalone and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and counsel against driving until response is known. Lower the metaxalone dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Metaxalone with Thioridazine?
MediHelp rates the interaction as moderate. Metaxalone and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine is a sedating phenothiazine, and together with metaxalone it can cause additive drowsiness and psychomotor impairment. Thioridazine also carries a QT prolongation risk, which is not altered by metaxalone but warrants attention in the overall regimen.
How serious is the interaction between Metaxalone and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and counsel against driving until response is known. Lower the metaxalone dose if sedation is excessive.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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