Drug interactions
Metformin + Pegvisomant
Severity: Minor
Metformin and Pegvisomant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action, improving insulin sensitivity and lowering glucose in acromegaly. This can add to the effect of antidiabetic drugs, so lower doses may be needed.
What this interaction means in plain words
Metformin and Pegvisomant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism increases insulin sensitivity, adding to metformin's glucose lowering.
What to do
Monitor blood glucose after starting pegvisomant and reduce antidiabetic doses if glucose falls, especially with insulin or sulfonylureas.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Metformin with Pegvisomant?
MediHelp rates the interaction as minor. Metformin and Pegvisomant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pegvisomant blocks growth hormone action, improving insulin sensitivity and lowering glucose in acromegaly. This can add to the effect of antidiabetic drugs, so lower doses may be needed.
How serious is the interaction between Metformin and Pegvisomant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting pegvisomant and reduce antidiabetic doses if glucose falls, especially with insulin or sulfonylureas.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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