Drug interactions
Metformin-pioglitazone + Tazemetostat
Severity: Minor
Metformin-pioglitazone and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone has been reported to induce CYP3A4 weakly, so it may slightly lower tazemetostat exposure. The clinical impact is uncertain and probably small.
What this interaction means in plain words
Metformin-pioglitazone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 induction by pioglitazone increases tazemetostat metabolism.
What to do
No dose adjustment is routinely needed. Monitor for reduced tazemetostat response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Tazemetostat
Frequently asked questions
Can I take Metformin-pioglitazone with Tazemetostat?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone has been reported to induce CYP3A4 weakly, so it may slightly lower tazemetostat exposure. The clinical impact is uncertain and probably small.
How serious is the interaction between Metformin-pioglitazone and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor for reduced tazemetostat response.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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