Drug interactions
Metformin-pioglitazone + Tipranavir
Severity: Moderate
Metformin-pioglitazone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as tipranavir can induce insulin resistance and hyperglycemia, which may reduce the glucose-lowering effect of metformin and pioglitazone. Tipranavir may also alter pioglitazone exposure through effects on hepatic metabolism, though this is poorly characterised.
What this interaction means in plain words
Metformin-pioglitazone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitor-related insulin resistance opposes antidiabetic action, and tipranavir may modulate CYP2C8/CYP3A4-mediated pioglitazone metabolism to an uncertain degree.
What to do
Monitor blood glucose and HbA1c after starting or stopping tipranavir and titrate the antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Tipranavir?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as tipranavir can induce insulin resistance and hyperglycemia, which may reduce the glucose-lowering effect of metformin and pioglitazone. Tipranavir may also alter pioglitazone exposure through effects on hepatic metabolism, though this is poorly characterised.
How serious is the interaction between Metformin-pioglitazone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping tipranavir and titrate the antidiabetic doses as needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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