Drug interactions
Metformin-pioglitazone + Voriconazole
Severity: Minor
Metformin-pioglitazone and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and CYP2C9/2C19 and may raise pioglitazone concentrations, although CYP2C8 is its main pathway. Increased exposure could add to fluid retention or hypoglycemia.
What this interaction means in plain words
Metformin-pioglitazone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibition of CYP3A4 reduces a secondary metabolic route of pioglitazone.
What to do
Monitor glucose and for edema while on voriconazole; lower the pioglitazone dose if hypoglycemia or fluid retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Voriconazole?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP3A4 and CYP2C9/2C19 and may raise pioglitazone concentrations, although CYP2C8 is its main pathway. Increased exposure could add to fluid retention or hypoglycemia.
How serious is the interaction between Metformin-pioglitazone and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and for edema while on voriconazole; lower the pioglitazone dose if hypoglycemia or fluid retention develops.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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