Drug interactions
Metformin-repaglinide + Moxifloxacin
Severity: Moderate
Metformin-repaglinide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can disturb glucose homeostasis and cause both hypoglycemia and hyperglycemia, particularly in patients taking antidiabetic drugs. Moxifloxacin carries a lower risk than some other quinolones, but severe dysglycemia can occur, especially in elderly or renally impaired patients.
What this interaction means in plain words
Metformin-repaglinide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Quinolones affect pancreatic beta-cell insulin release, producing additive pharmacodynamic effects on glycemic control with insulin secretagogues such as repaglinide.
What to do
Monitor blood glucose closely during and shortly after the antibiotic course and counsel the patient on symptoms of hypo- and hyperglycemia. Stop the quinolone and switch to another antibiotic class if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Moxifloxacin?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can disturb glucose homeostasis and cause both hypoglycemia and hyperglycemia, particularly in patients taking antidiabetic drugs. Moxifloxacin carries a lower risk than some other quinolones, but severe dysglycemia can occur, especially in elderly or renally impaired patients.
How serious is the interaction between Metformin-repaglinide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and shortly after the antibiotic course and counsel the patient on symptoms of hypo- and hyperglycemia. Stop the quinolone and switch to another antibiotic class if significant dysglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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