Drug interactions
Metformin-repaglinide + Perphenazine
Severity: Moderate
Metformin-repaglinide and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as perphenazine can raise blood glucose and impair glucose tolerance, possibly reducing the effect of antidiabetic drugs.
What this interaction means in plain words
Metformin-repaglinide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Antipsychotic-induced insulin resistance and reduced insulin secretion oppose antidiabetic drug action.
What to do
Monitor blood glucose when starting or stopping perphenazine and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Metformin-repaglinide with Perphenazine?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as perphenazine can raise blood glucose and impair glucose tolerance, possibly reducing the effect of antidiabetic drugs.
How serious is the interaction between Metformin-repaglinide and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping perphenazine and adjust antidiabetic doses as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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