Drug interactions
Metformin-repaglinide + Phentermine
Severity: Minor
Metformin-repaglinide and Phentermine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine may modestly affect glucose through sympathomimetic activity, while associated weight loss typically improves glycemia and may lower antidiabetic requirements. The net effect is variable and usually small.
What this interaction means in plain words
Metformin-repaglinide and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Phentermine belongs to Central Nervous System.
Why it happens
Opposing effects of sympathomimetic activity and weight loss on glycemic control; no direct interaction.
What to do
Monitor blood glucose during phentermine therapy and reduce antidiabetic doses if hypoglycemia occurs with weight loss.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Phentermine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phentermine may modestly affect glucose through sympathomimetic activity, while associated weight loss typically improves glycemia and may lower antidiabetic requirements. The net effect is variable and usually small.
How serious is the interaction between Metformin-repaglinide and Phentermine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during phentermine therapy and reduce antidiabetic doses if hypoglycemia occurs with weight loss.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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