Drug interactions
Metformin-repaglinide + Pravastatin
Severity: Minor
Metformin-repaglinide and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is an OATP1B1 substrate with some inhibitory potential, and the effect on pravastatin exposure is small and not clearly clinically significant. Pravastatin has little effect on metformin or repaglinide.
What this interaction means in plain words
Metformin-repaglinide and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Pravastatin belongs to Cardiovascular.
Why it happens
Possible weak OATP1B1 competition may modestly raise pravastatin levels.
What to do
No dose change is needed; counsel the patient to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Pravastatin
Frequently asked questions
Can I take Metformin-repaglinide with Pravastatin?
MediHelp rates the interaction as minor. Metformin-repaglinide and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is an OATP1B1 substrate with some inhibitory potential, and the effect on pravastatin exposure is small and not clearly clinically significant. Pravastatin has little effect on metformin or repaglinide.
How serious is the interaction between Metformin-repaglinide and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; counsel the patient to report unexplained muscle pain or weakness.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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