Drug interactions
Metformin-repaglinide + Ribociclib
Severity: Moderate
Metformin-repaglinide and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and can increase exposure to repaglinide, which is cleared by CYP3A4 and CYP2C8. This may cause hypoglycemia. Ribociclib also prolongs the QT interval, but this is not specific to the interaction.
What this interaction means in plain words
Metformin-repaglinide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated repaglinide metabolism increases repaglinide plasma concentrations.
What to do
Monitor blood glucose closely and consider a lower repaglinide dose while on ribociclib. Counsel the patient on recognizing hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Ribociclib?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and can increase exposure to repaglinide, which is cleared by CYP3A4 and CYP2C8. This may cause hypoglycemia. Ribociclib also prolongs the QT interval, but this is not specific to the interaction.
How serious is the interaction between Metformin-repaglinide and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider a lower repaglinide dose while on ribociclib. Counsel the patient on recognizing hypoglycemia.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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