Drug interactions
Metformin-repaglinide + Rosuvastatin
Severity: Minor
Metformin-repaglinide and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is an OATP1B1 inhibitor in vitro and could raise rosuvastatin exposure, raising theoretical myopathy risk. Clinical significance at usual doses appears small.
What this interaction means in plain words
Metformin-repaglinide and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of rosuvastatin.
What to do
No routine dose change is needed; advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Metformin-repaglinide with Rosuvastatin?
MediHelp rates the interaction as minor. Metformin-repaglinide and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is an OATP1B1 inhibitor in vitro and could raise rosuvastatin exposure, raising theoretical myopathy risk. Clinical significance at usual doses appears small.
How serious is the interaction between Metformin-repaglinide and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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