Drug interactions
Metformin-repaglinide + Sirolimus
Severity: Moderate
Metformin-repaglinide and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus can cause hyperglycemia and insulin resistance and may worsen glycemic control in diabetic patients taking metformin or repaglinide. Dose adjustment of antidiabetic therapy may be needed.
What this interaction means in plain words
Metformin-repaglinide and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
Sirolimus-induced insulin resistance and impaired beta-cell function oppose antidiabetic effects.
What to do
Monitor blood glucose and HbA1c after starting sirolimus and intensify antidiabetic treatment as necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Sirolimus?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus can cause hyperglycemia and insulin resistance and may worsen glycemic control in diabetic patients taking metformin or repaglinide. Dose adjustment of antidiabetic therapy may be needed.
How serious is the interaction between Metformin-repaglinide and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting sirolimus and intensify antidiabetic treatment as necessary.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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