Drug interactions
Metformin-repaglinide + Tacrolimus
Severity: Moderate
Metformin-repaglinide and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is diabetogenic and can impair insulin secretion, leading to hyperglycemia and reduced effectiveness of oral antidiabetic agents. Renal toxicity from tacrolimus may also affect metformin safety.
What this interaction means in plain words
Metformin-repaglinide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus-induced beta-cell toxicity and insulin resistance oppose antidiabetic effect.
What to do
Monitor blood glucose and renal function; adjust antidiabetic therapy, and stop metformin if eGFR falls markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Tacrolimus?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus is diabetogenic and can impair insulin secretion, leading to hyperglycemia and reduced effectiveness of oral antidiabetic agents. Renal toxicity from tacrolimus may also affect metformin safety.
How serious is the interaction between Metformin-repaglinide and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function; adjust antidiabetic therapy, and stop metformin if eGFR falls markedly.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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