Drug interactions
Metformin-repaglinide + Talquetamab
Severity: Moderate
Metformin-repaglinide and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release that can temporarily suppress CYP enzyme activity, which may raise repaglinide exposure. The risk is greatest during step-up dosing and around cytokine release syndrome episodes, with hypoglycemia as the concern.
What this interaction means in plain words
Metformin-repaglinide and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP450 enzymes reduces repaglinide metabolism.
What to do
Monitor blood glucose closely during step-up dosing and any cytokine release syndrome, and reduce repaglinide if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Talquetamab?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release that can temporarily suppress CYP enzyme activity, which may raise repaglinide exposure. The risk is greatest during step-up dosing and around cytokine release syndrome episodes, with hypoglycemia as the concern.
How serious is the interaction between Metformin-repaglinide and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during step-up dosing and any cytokine release syndrome, and reduce repaglinide if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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