Drug interactions
Metformin-repaglinide + Tecovirimat
Severity: Moderate
Metformin-repaglinide and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat weakly inhibits CYP2C8 and CYP2C19 and weakly induces CYP3A4, so repaglinide exposure may change in either direction. Hypoglycemia has been reported with this combination and is the main clinical concern.
What this interaction means in plain words
Metformin-repaglinide and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP2C8 inhibition and weak CYP3A4 induction alter repaglinide metabolism.
What to do
Monitor blood glucose and hypoglycemia symptoms during tecovirimat therapy and adjust repaglinide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Tecovirimat?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat weakly inhibits CYP2C8 and CYP2C19 and weakly induces CYP3A4, so repaglinide exposure may change in either direction. Hypoglycemia has been reported with this combination and is the main clinical concern.
How serious is the interaction between Metformin-repaglinide and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and hypoglycemia symptoms during tecovirimat therapy and adjust repaglinide dose if needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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