Drug interactions
Metformin-repaglinide + Tipranavir
Severity: Moderate
Metformin-repaglinide and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, boosted with ritonavir, can cause insulin resistance and hyperglycemia, reducing the effectiveness of antidiabetic drugs. It also affects CYP3A4 and may alter repaglinide exposure, so glucose control can be unpredictable.
What this interaction means in plain words
Metformin-repaglinide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance opposes glucose lowering, and tipranavir/ritonavir modulation of CYP3A4 may alter repaglinide metabolism.
What to do
Monitor blood glucose closely when starting or stopping tipranavir and adjust the antidiabetic regimen based on readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Tipranavir?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, boosted with ritonavir, can cause insulin resistance and hyperglycemia, reducing the effectiveness of antidiabetic drugs. It also affects CYP3A4 and may alter repaglinide exposure, so glucose control can be unpredictable.
How serious is the interaction between Metformin-repaglinide and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping tipranavir and adjust the antidiabetic regimen based on readings.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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