Drug interactions
Metformin-repaglinide + Torsemide
Severity: Moderate
Metformin-repaglinide and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics may raise blood glucose modestly and cause volume depletion that can impair renal function, raising metformin accumulation risk.
What this interaction means in plain words
Metformin-repaglinide and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic-related impairment of glucose tolerance and potential volume depletion reducing renal metformin clearance.
What to do
Monitor blood glucose and renal function; hold metformin during dehydration or acute kidney injury.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metformin-repaglinide and Torsemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-repaglinide
Other interactions of Torsemide
Frequently asked questions
Can I take Metformin-repaglinide with Torsemide?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics may raise blood glucose modestly and cause volume depletion that can impair renal function, raising metformin accumulation risk.
How serious is the interaction between Metformin-repaglinide and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function; hold metformin during dehydration or acute kidney injury.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
