Drug interactions
Metformin-repaglinide + Voriconazole
Severity: Moderate
Metformin-repaglinide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and can increase repaglinide concentrations, raising the risk of hypoglycemia.
What this interaction means in plain words
Metformin-repaglinide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated repaglinide metabolism increases repaglinide exposure.
What to do
Monitor blood glucose closely and consider reducing the repaglinide dose during voriconazole therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Voriconazole?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and can increase repaglinide concentrations, raising the risk of hypoglycemia.
How serious is the interaction between Metformin-repaglinide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the repaglinide dose during voriconazole therapy.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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