Drug interactions
Metformin-sitagliptin + Midodrine
Severity: Minor
Metformin-sitagliptin and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine's active metabolite is a renally secreted cation, so competition for tubular secretion with metformin is theoretically possible. Clinically relevant effects have not been established.
What this interaction means in plain words
Metformin-sitagliptin and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Midodrine belongs to Miscellaneous.
Why it happens
Possible competition for renal tubular secretion via organic cation transporters.
What to do
No dose change is generally needed; monitor renal function and for metformin adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Metformin-sitagliptin with Midodrine?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midodrine's active metabolite is a renally secreted cation, so competition for tubular secretion with metformin is theoretically possible. Clinically relevant effects have not been established.
How serious is the interaction between Metformin-sitagliptin and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor renal function and for metformin adverse effects in patients with renal impairment.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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