Drug interactions
Metformin-sitagliptin + Temsirolimus
Severity: Moderate
Metformin-sitagliptin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus frequently causes hyperglycemia, which can worsen control in patients taking metformin-sitagliptin. Antidiabetic requirements may increase during therapy.
What this interaction means in plain words
Metformin-sitagliptin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Temsirolimus belongs to Oncology.
Why it happens
mTOR inhibition induces insulin resistance and impairs glucose handling, opposing antidiabetic drugs.
What to do
Monitor blood glucose frequently during temsirolimus treatment and intensify antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Temsirolimus?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus frequently causes hyperglycemia, which can worsen control in patients taking metformin-sitagliptin. Antidiabetic requirements may increase during therapy.
How serious is the interaction between Metformin-sitagliptin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during temsirolimus treatment and intensify antidiabetic therapy as required.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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