Drug interactions
Metformin-sitagliptin + Vadadustat
Severity: Minor
Metformin-sitagliptin and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits OAT3 and may modestly raise exposure to sitagliptin, which is partly eliminated through this transporter. Sitagliptin has a wide safety margin, so clinical impact is likely limited.
What this interaction means in plain words
Metformin-sitagliptin and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT3-mediated renal secretion of sitagliptin.
What to do
No routine dose change is needed. Monitor for sitagliptin adverse effects, particularly in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Metformin-sitagliptin with Vadadustat?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits OAT3 and may modestly raise exposure to sitagliptin, which is partly eliminated through this transporter. Sitagliptin has a wide safety margin, so clinical impact is likely limited.
How serious is the interaction between Metformin-sitagliptin and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for sitagliptin adverse effects, particularly in renal impairment.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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