Drug interactions
Methadone + Osimertinib
Severity: Major
Methadone and Osimertinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so concurrent use increases the potential for ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Methadone and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methadone belongs to Musculoskeletal; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform periodic ECG monitoring and maintain normal potassium and magnesium. Reassess therapy if QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Methadone with Osimertinib?
MediHelp rates the interaction as major. Methadone and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so concurrent use increases the potential for ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Methadone and Osimertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and maintain normal potassium and magnesium. Reassess therapy if QTc becomes significantly prolonged.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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