Drug interactions
Methadone + Selinexor
Severity: Moderate
Methadone and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and can cause neurological toxicity. Methadone adds sedation and cognitive impairment, which may worsen these effects and raise the risk of falls or accidents.
What this interaction means in plain words
Methadone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methadone belongs to Musculoskeletal; Selinexor belongs to Oncology.
Why it happens
Additive CNS effects; no pharmacokinetic mechanism established.
What to do
Monitor for dizziness, confusion and oversedation and counsel patients against driving. Reduce the methadone dose or adjust selinexor if neurological symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Methadone with Selinexor?
MediHelp rates the interaction as moderate. Methadone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and can cause neurological toxicity. Methadone adds sedation and cognitive impairment, which may worsen these effects and raise the risk of falls or accidents.
How serious is the interaction between Methadone and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and oversedation and counsel patients against driving. Reduce the methadone dose or adjust selinexor if neurological symptoms emerge.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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