Drug interactions
Methadone + Tecovirimat
Severity: Minor
Methadone and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and a weak inhibitor of CYP2C8 and CYP2C19, which participate in methadone metabolism. Net effects on methadone exposure are likely small but unpredictable.
What this interaction means in plain words
Methadone and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methadone belongs to Musculoskeletal; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction with weak CYP2C8 and CYP2C19 inhibition.
What to do
Monitor for withdrawal or opioid toxicity during the short tecovirimat course and adjust methadone if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Methadone with Tecovirimat?
MediHelp rates the interaction as minor. Methadone and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and a weak inhibitor of CYP2C8 and CYP2C19, which participate in methadone metabolism. Net effects on methadone exposure are likely small but unpredictable.
How serious is the interaction between Methadone and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal or opioid toxicity during the short tecovirimat course and adjust methadone if clinically indicated.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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