Drug interactions
Methamphetamine + Methoxyflurane
Severity: Major
Methamphetamine and Methoxyflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Halogenated inhaled anesthetics sensitise the myocardium to catecholamines, and amphetamines increase catecholamine activity. Together they may cause ventricular arrhythmias and hypertension. Methoxyflurane is also nephrotoxic, which adds to the concern.
What this interaction means in plain words
Methamphetamine and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic: myocardial sensitisation to catecholamines by methoxyflurane plus sympathomimetic stimulation from methamphetamine.
What to do
Avoid methoxyflurane in patients who have recently taken methamphetamine, and choose another analgesic or anesthetic. If it cannot be avoided, monitor ECG and blood pressure continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Methoxyflurane?
MediHelp rates the interaction as major. Methamphetamine and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Halogenated inhaled anesthetics sensitise the myocardium to catecholamines, and amphetamines increase catecholamine activity. Together they may cause ventricular arrhythmias and hypertension. Methoxyflurane is also nephrotoxic, which adds to the concern.
How serious is the interaction between Methamphetamine and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid methoxyflurane in patients who have recently taken methamphetamine, and choose another analgesic or anesthetic. If it cannot be avoided, monitor ECG and blood pressure continuously.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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