Drug interactions
Methamphetamine + Methylergonovine
Severity: Major
Methamphetamine and Methylergonovine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine releases catecholamines and causes vasoconstriction, while methylergonovine is an ergot alkaloid with strong vasoconstrictor activity. Together they can produce severe hypertension and peripheral or coronary vasospasm.
What this interaction means in plain words
Methamphetamine and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic vasoconstriction from sympathomimetic amine release and ergot alpha-adrenergic/serotonergic agonism.
What to do
Avoid the combination where possible; if methylergonovine is needed for postpartum hemorrhage, monitor blood pressure closely and consider alternative uterotonics. Stop and treat promptly if severe hypertension or ischemic symptoms develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Methylergonovine?
MediHelp rates the interaction as major. Methamphetamine and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methamphetamine releases catecholamines and causes vasoconstriction, while methylergonovine is an ergot alkaloid with strong vasoconstrictor activity. Together they can produce severe hypertension and peripheral or coronary vasospasm.
How serious is the interaction between Methamphetamine and Methylergonovine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if methylergonovine is needed for postpartum hemorrhage, monitor blood pressure closely and consider alternative uterotonics. Stop and treat promptly if severe hypertension or ischemic symptoms develop.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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