Drug interactions
Methamphetamine + Norepinephrine
Severity: Major
Methamphetamine and Norepinephrine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is a potent vasopressor, and methamphetamine increases norepinephrine release and vascular tone. Together they can produce an exaggerated pressor response with severe hypertension, tachycardia and arrhythmia.
What this interaction means in plain words
Methamphetamine and Norepinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive adrenergic stimulation, with methamphetamine increasing synaptic norepinephrine.
What to do
Titrate norepinephrine infusions carefully using continuous blood pressure and ECG monitoring. Anticipate lower dose requirements in patients who have recently used methamphetamine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Norepinephrine?
MediHelp rates the interaction as major. Methamphetamine and Norepinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Norepinephrine is a potent vasopressor, and methamphetamine increases norepinephrine release and vascular tone. Together they can produce an exaggerated pressor response with severe hypertension, tachycardia and arrhythmia.
How serious is the interaction between Methamphetamine and Norepinephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate norepinephrine infusions carefully using continuous blood pressure and ECG monitoring. Anticipate lower dose requirements in patients who have recently used methamphetamine.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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