Drug interactions
Methamphetamine + Pholcodine
Severity: Minor
Methamphetamine and Pholcodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid cough suppressant with mild sedative activity, whereas methamphetamine is a stimulant. The effects on alertness are opposed, and no meaningful clinical interaction is well documented at antitussive doses.
What this interaction means in plain words
Methamphetamine and Pholcodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing central nervous system effects; no established pharmacokinetic mechanism.
What to do
No routine adjustment is needed. Counsel the patient that stimulation may mask drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methamphetamine and Pholcodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Pholcodine?
MediHelp rates the interaction as minor. Methamphetamine and Pholcodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pholcodine is an opioid cough suppressant with mild sedative activity, whereas methamphetamine is a stimulant. The effects on alertness are opposed, and no meaningful clinical interaction is well documented at antitussive doses.
How serious is the interaction between Methamphetamine and Pholcodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Counsel the patient that stimulation may mask drowsiness.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
