Drug interactions
Methamphetamine + Quinacrine
Severity: Minor
Methamphetamine and Quinacrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, which contributes to methamphetamine metabolism, so methamphetamine exposure could increase. This may intensify stimulant and cardiovascular effects.
What this interaction means in plain words
Methamphetamine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP2D6-mediated metabolism of methamphetamine; the interaction is largely theoretical.
What to do
Monitor for heightened stimulant effects such as tachycardia, hypertension and agitation. Reduce the methamphetamine dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Quinacrine?
MediHelp rates the interaction as minor. Methamphetamine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinacrine may inhibit CYP2D6, which contributes to methamphetamine metabolism, so methamphetamine exposure could increase. This may intensify stimulant and cardiovascular effects.
How serious is the interaction between Methamphetamine and Quinacrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for heightened stimulant effects such as tachycardia, hypertension and agitation. Reduce the methamphetamine dose if these occur.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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