Drug interactions
Methamphetamine + Sufentanil sl
Severity: Moderate
Methamphetamine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine increases serotonergic and noradrenergic activity, and some opioids with serotonergic action have been linked to serotonin syndrome. Sufentanil has limited serotonergic activity, so the risk is low. The opposing effects on arousal can also hide opioid sedation.
What this interaction means in plain words
Methamphetamine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effect, though this is poorly established for sufentanil; also opposing central nervous system effects.
What to do
Monitor for agitation, tremor, hyperthermia and autonomic instability, and track respiratory rate and sedation level. Reassess if symptoms of serotonin toxicity develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Sufentanil sl?
MediHelp rates the interaction as moderate. Methamphetamine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine increases serotonergic and noradrenergic activity, and some opioids with serotonergic action have been linked to serotonin syndrome. Sufentanil has limited serotonergic activity, so the risk is low. The opposing effects on arousal can also hide opioid sedation.
How serious is the interaction between Methamphetamine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and autonomic instability, and track respiratory rate and sedation level. Reassess if symptoms of serotonin toxicity develop.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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