Drug interactions
Methamphetamine + Venlafaxine
Severity: Moderate
Methamphetamine and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine weakly inhibits CYP2D6, which contributes to methamphetamine metabolism, potentially raising its levels. Both drugs also increase monoaminergic and cardiovascular stimulation, so serotonin syndrome and hypertension are possible.
What this interaction means in plain words
Methamphetamine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition plus additive serotonergic and noradrenergic effects.
What to do
Monitor blood pressure, heart rate and signs of serotonin toxicity, and use the lowest effective methamphetamine dose. Reduce the dose if stimulant effects are excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methamphetamine and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Venlafaxine?
MediHelp rates the interaction as moderate. Methamphetamine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine weakly inhibits CYP2D6, which contributes to methamphetamine metabolism, potentially raising its levels. Both drugs also increase monoaminergic and cardiovascular stimulation, so serotonin syndrome and hypertension are possible.
How serious is the interaction between Methamphetamine and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of serotonin toxicity, and use the lowest effective methamphetamine dose. Reduce the dose if stimulant effects are excessive.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
