Drug interactions
Methamphetamine + Yohimbe
Severity: Major
Methamphetamine and Yohimbe: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe contains yohimbine, an alpha-2 antagonist that raises noradrenergic outflow, and methamphetamine also increases catecholamine release. The combination can cause marked hypertension, tachycardia, anxiety and arrhythmias.
What this interaction means in plain words
Methamphetamine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive sympathomimetic effects: alpha-2 blockade increasing norepinephrine release plus amphetamine-induced monoamine release.
What to do
Avoid concurrent use and advise patients to stop yohimbe products. Monitor blood pressure and heart rate if exposure has occurred.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Yohimbe?
MediHelp rates the interaction as major. Methamphetamine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbe contains yohimbine, an alpha-2 antagonist that raises noradrenergic outflow, and methamphetamine also increases catecholamine release. The combination can cause marked hypertension, tachycardia, anxiety and arrhythmias.
How serious is the interaction between Methamphetamine and Yohimbe?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and advise patients to stop yohimbe products. Monitor blood pressure and heart rate if exposure has occurred.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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